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[Analysis Case] Evaluation of the Distribution of Active Ingredients in Tablets

The distribution of main components and additives can be visualized.

Among the various forms of medication, tablets are widely used, but not much is known about the state of each component within them. To gain insights into the distribution of active ingredients within tablets, we conducted TOF-SIMS analysis on the cross-section of commercially available cold medicine tablets. In the outer layer of the tablet, SiO2, presumed to be derived from lubricant components, was detected almost uniformly, while inside, the active ingredients acetaminophen, anhydrous caffeine, dl-methyl ephedrine, and noscapine were found to be dispersed in different areas.